Oxytocin has different effects on stress in male and female mice

first_img“Reduced social motivation can be part of a depression-like syndrome,” said Trainor, an associate professor of psychology.Trainor and colleagues found important differences in how stress affected the production of oxytocin. After stress, nerve cells in the brain produced more oxytocin in females but not in males. Steinman used a molecular marker to show that these oxytocin-producing cells were also more active in females that experienced stress. Steinman suggests, “This may help explain why oxytocin nasal spray makes females avoid social contact even though they did not experience social stress.”Clinical studies have found that women with depression or PTSD have elevated oxytocin levels. Usually this result has been thought to reflect an increased drive for social support. The results of Trainor and colleagues suggest an alternate possibility.“Our results show that stressed females have both reduced social motivation and increased oxytocin. It’s possible that oxytocin might contribute to a depression-like syndrome in females,” Trainor said. “If correct, inhibiting oxytocin action might have unanticipated benefits.”The surrounding environment also influenced the effects of oxytocin. If mice were tested in a familiar home cage instead of a new environment, oxytocin reduced stress-related behaviors in males and females. This finding shows that the effects of oxytocin depend whether the environment is familiar or unfamiliar.Trainor said his lab’s findings have implications for studies investigating the utility of oxytocin as a therapeutic. “Most clinical studies investigating oxytocin as a treatment for depression or anxiety include only males,” he said. “It’s important to include both men and women in these studies. The effect of oxytocin may be different if administered by an unfamiliar person or by a person with whom the patient has a personal relationship.”The UC Davis research project was supported by the National Institutes of Mental Health and are published in the journal Biological Psychiatry. Share on Twitter LinkedIn Clinical trials are testing whether oxytocin, sometimes called the “love hormone” for its role in intimacy and social bonding, has potential as a treatment for anxiety, depression and post-traumatic stress disorder. New research by behavioral neuroscientists Michael Steinman, Brian Trainor and colleagues at the University of California, Davis, suggests oxytocin may have different effects in men and women–and in certain circumstances the hormone may actually trigger anxiety.In a series of experiments at the UC Davis Department of Psychology, the team administered doses of oxytocin with a nasal spray to male and female mice. Some of the mice were bullied by an aggressive mouse, an experience that reduces motivation to associate with unfamiliar mice. Consistent with previous studies, oxytocin increased the motivation for social interaction in stressed males.However, in stressed females, oxytocin had no effect. When non-stressed females received oxytocin, social motivation was reduced. This effect of oxytocin is similar to the effect of social stress. Emailcenter_img Pinterest Share Share on Facebooklast_img read more

World’s first CNG carrier to be powered by Wartsila

first_imgThe world’s first ever carrier vessel for compressed natural gas is to be powered by an integrated Wärtsilä propulsion system.The vessel is being built at the Jiangsu Hantong shipyard in China ordered by CIMC ENRIC and designed by CIMC ORIC for end user Perusahaan Listrik Negara, the Indonesian state-owned energy company. The order with Wärtsilä was placed during the fourth quarter, 2014, the company informed in a statement.The new vessel will feature a 9-cylinder Wärtsilä 34DF dual-fuel main engine operating primarily on gas. Wärtsilä will also supply the controlled pitch propeller and gearbox, all of which will be fully integrated so as to optimise the propulsion efficiency.This will be the first dual-fuel powered vessel owned by an Indonesian ship owner.The 110 metre long carrier is scheduled to be in operation in May 2016 and will transport CNG from Gresik in East Java to the Indonesian island of Lombok where the gas will be used to fuel a power plant.[mappress mapid=”16544″]last_img read more

Rail approved cable glands at InnoTrans 2018

first_imgCMP: Cable gland, cleat and accessory specialist CMP will be showcasing its range of rail-specific products, which have been supplied for high-profile projects including London’s Crossrail and metro lines in Dubai and Doha.TruSeal is the company’s new range of polymer cable glands to suit a variety of industrial applications. Also on display will be the SOLO cable gland range, manufactured from low smoke and fume materials and approved for use on the London Underground.last_img

Molinari becomes first Italian major champion

first_imgCARNOUSTIE, Scotland, (Reuters) – Francesco Molinari kept the coolest head in Carnoustie as he steered a steady course through a wild afternoon of nailbiting tension at the British Open yesterday to become the first Italian major champion. With a strong breeze causing mayhem at the top of the leaderboard which a charging Tiger Woods had topped with nine holes to play, the 35-year-old Molinari buckled down to produce a flawless 69 and claim victory by two strokes.Overnight leaders Xander Schauffele and Kevin Kisner ended two shots back in four-way tie for second place with England’s Justin Rose and Northern Ireland’s Rory McIlroy.Molinari ended a compelling four-day drama on eight-under 276 — the lowest combined score in the eight Carnoustie Opens. Huge crowds descended on the seaside links and the majority were willing Woods to claim a fairytale 15th major a decade after his last one. But it was the American’s playing partner Molinari who wrote his own script to claim his major breakthrough at the 36th time of asking.With defending champion Jordan Spieth, Woods, English duo Rose and Tommy Fleetwood and McIlroy in the mix yesterday, the Molinari sub-plot was almost overlooked as the leading groups went out.Yet his recent form, two wins and two runners-up finishes in his last five tournaments, should have served as a warning on a day when a steady hand was needed on the tiller. While Spieth, Schauffele and Kisner endured a rollercoaster ride across the sun-blasted links, as if spooked by the presence of a resurgent Woods, Molinari cranked out 13 consecutive pars before making his move.He rolled in a birdie on the par-five 14th to move into the lead on seven-under.With Rose and McIlroy in the clubhouse on six-under, Schauffele fought back from a 40-stroke outward nine to get to seven-under but Molinari was unflappable. Carnoustie’s 18th hole has witnessed its fair share of horror shows but Molinari safely negotiated the snaking Barry Burn with his tee shot before planting his second to six feet.Molinari was a picture of calm as he walked up to his putt and only after it disappeared into the cup did he allow his mask to slip — turning to punch the air.last_img read more

Garage Sales for this weekend…

first_imgby Tracy McCue, Sumner Newscow — The following are the garage sales that we have for the weekend of Nov. 11-13, 2016. If you still need a garage sale advertised just use the comment section below. Good luck with bargain hunting! Follow us on Facebook.Follow us on Twitter. Close Forgot password? Please put in your email: Send me my password! Close message Login This blog post All blog posts Subscribe to this blog post’s comments through… RSS Feed Subscribe via email Subscribe Subscribe to this blog’s comments through… RSS Feed Subscribe via email Subscribe Follow the discussion Comments (4) Logging you in… Close Login to IntenseDebate Or create an account Username or Email: Password: Forgot login? Cancel Login Close WordPress.com Username or Email: Password: Lost your password? Cancel Login Dashboard | Edit profile | Logout Logged in as Admin Options Disable comments for this page Save Settings Sort by: Date Rating Last Activity Loading comments… You are about to flag this comment as being inappropriate. Please explain why you are flagging this comment in the text box below and submit your report. The blog admin will be notified. Thank you for your input. 0 Vote up Vote down Richard Crowe · 196 weeks ago 801 S. C St , Wellington . Large sale in Driveway . Friday 12 noon till 5 pm , Saturday from 9 am till 2 pm . Lots of New things !!! Must See !! Report Reply 0 replies · active 196 weeks ago 0 Vote up Vote down Mikel Hartley · 196 weeks ago Garage Sale 1211 South H Saturday November 12th 8:00 to 3:00. Womens clothes, books, castiron skillets,collectables, New gazebo in box, 15″ chevy rally wheels,and lots of stuff !!! Report Reply 0 replies · active 196 weeks ago 0 Vote up Vote down Inez Glamann · 195 weeks ago November 12 8:00 AM – 1:00 PM 422 Circle Drive Fishing equipment, kitchen utensils, tools, books, large Oriental screen, jewelry, movies, carved ivory netsuke, misc. Good opportunity for some Christmas gifts! Report Reply 0 replies · active 195 weeks ago 0 Vote up Vote down Andy Shimer · 195 weeks ago Yard Sale 614 N B 11/12-11/13 Kitchen, frames, pictures, clothes, electronics, speakers Report Reply 0 replies · active 195 weeks ago Post a new comment Enter text right here! Comment as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. If you have a website, link to it here. Posting anonymously. Tweet this comment Submit Comment Subscribe to None Replies All new comments Comments by IntenseDebate Enter text right here! Reply as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. If you have a website, link to it here. Posting anonymously. Tweet this comment Cancel Submit Comment Subscribe to None Replies All new commentslast_img read more

Pragmatic multiracial politics

first_imgWith the funeral rites about to be read over the AFC at the LGE, there are once again calls for a “multiracial” party. Now, what is a “multi-racial” party? Is it one in which the leaders are drawn from all or most of the various racial/ethnic blocs that constitute our polity? Is it one that has members drawn from all the various groups? Do the proportions have to roughly mirror the population, or will any assorted agglomeration (like APNU/AFC) do? Or does it mean that the interests of all the groups must be expressly articulated and represented? Should those interests be subsumed under some notion of a “national” interest? Who defines that “national” interest? And so on.In Guyana, all political parties before ROAR claimed they were “multiracial”. They took special pains to have individuals from the major race groups in their executive, and courted votes from across the spectrum. They constructed “national” manifestos. Yet, when it came to elections, the majority of the people invariably voted for one of the two major parties which were firmly identified with specific ethnic blocs – the PPP with Indians and the PNC with Africans. This even occurred with the carefully crafted “multiracial” AFC in 2011 and 2015. So the question is posed again: “What is an “authentic” multiracial party?”The question harks back to the roots of what constitutes “representation” in our “representative democracy”. The favoured approach from both the old Liberal and Marxist ideologies was the “representation of ideas”. That is, once the interests of the group are articulated, then anyone could “speak” for the group. By constructing “national” platforms in personnel and content, the PPP, the PNC and the AFC claimed to be capable of speaking for “all”. Yet, based on the results of elections, it is obvious in some way that the people were getting “ethnic” signals as to which party better represented their interests.ROAR’s precursor, Jaguar Committee for Democracy’s insertion into Guyanese politics occurred in the immediate pre-1992 years, and the free and fair elections of that year proved its thesis that “multiracial” voting remained the exception in Guyana. At that time, as articulated in our 1990 paper, “For a New Political Culture”, we proposed representative, professionalized, disciplined forces and temporary Shared Governance – segueing into federalism – to address the ethnic concerns over control of state power. If the status quo were retained, our theory predicted ethnic violence, which unfortunately came to pass in 1997 and the following decade.So how do we arrive at “multiracial” politics that can represent all the groups to their satisfaction? We thought it was self-evident that the parties that the various ethnic groups selected via their votes should come together and work on a programme that combined their several platforms. We still believe that this is the way to begin, and then work towards a federal approach, which would need the trust engendered during a period of working together.But a final piece of semantic confusion still remains, in addition to the need for political will. There still remains a distaste by the political parties to acknowledge they are “ethnically” based. The greatest irony is that this acknowledgement, coupled with the acceptance to work together, would result in “multiracial” governance, which, after all, is what they claim to be the goal of their politics. The “multiracial” party was supposed to only be a way-station to the “multiracial” government, wasn’t it?A multiracial/multiethnic party must explicitly articulate the interests of the several constituent groups it purports to represent. This can be done, as in the Democratic party in the US, by having specific “caucuses” for African and Hispanic voters. There is no shame in this, or apologies to be made. It is now conceded that in addition to the old “representation of ideas,” there is the need for “representation by presence”, especially for those who have been excluded or have experienced unique defining experiences. Can’t we at least go this far in Guyana? We have quotas for women representatives.“Representation by presence”, by its operation, has its own liberating potential. There are some who sincerely want to belong to “non-racial” parties, but I do not think we can create ever this unicorn in Guyana. Where has it been created? We have to work with the material we have: politics has to be pragmatic in the philosophical sense of the word.last_img read more